{"id":8080,"date":"2021-04-07T12:14:05","date_gmt":"2021-04-07T12:14:05","guid":{"rendered":"http:\/\/www.amarintech.com\/?p=8080"},"modified":"2021-06-18T16:26:51","modified_gmt":"2021-06-18T16:26:51","slug":"world-parkinsons-day","status":"publish","type":"post","link":"https:\/\/amarintech.com\/es\/world-parkinsons-day\/","title":{"rendered":"D\u00eda Mundial del Parkinson"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"8080\" class=\"elementor elementor-8080\">\n\t\t\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-c78867c elementor-section-height-min-height she-header-yes elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c78867c\" data-element_type=\"section\" 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d=\"M766.1,28.9c-200-57.5-266,65.5-395.1,19.5C242,1.8,242,5.4,184.8,20.6C128,35.8,132.3,44.9,89.9,52.5C28.6,63.7,0,0,0,0 h1000c0,0-9.9,40.9-83.6,48.1S829.6,47,766.1,28.9z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c82bb91\" data-id=\"c82bb91\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e6195d elementor-widget elementor-widget-heading\" data-id=\"2e6195d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">D\u00eda Mundial del Parkinson<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-62b6c1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"62b6c1f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-97230eb\" data-id=\"97230eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-003eebf elementor-widget elementor-widget-spacer\" data-id=\"003eebf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a8f378 elementor-widget elementor-widget-text-editor\" data-id=\"5a8f378\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Por Sebasti\u00e1n Godoy \u2013 Supervisor de Desarrollo<\/strong><strong>visor<\/strong><\/p><h2>\u00bfQu\u00e9 es el Parkinson?<\/h2><p>El Parkinson es una enfermedad producida por un proceso neurodegenerativo multisist\u00e9mico que afecta al sistema nervioso central provocando la aparici\u00f3n de s\u00edntomas motores y no motores. Es una enfermedad cr\u00f3nica y tanto su intensidad como la velocidad de progresi\u00f3n es propia de cada paciente.<\/p><p>Esta enfermedad representa el segundo trastorno neurodegenerativo por su frecuencia, situ\u00e1ndose por detr\u00e1s de la enfermedad de Alzheimer. Se encuentra extendida por todo el mundo y afecta tanto al sexo masculino como al femenino, afectando entre un 1 % a un 2 % de la poblaci\u00f3n por encima de los 60 a\u00f1os o de un 0,5 % a un 5 % de la poblaci\u00f3n mayor de 65 a\u00f1os.<\/p><p>Al d\u00eda de hoy, se desconoce la causa de su origen, sin embargo, se considera que podr\u00eda deberse a una combinaci\u00f3n de factores gen\u00e9ticos, medioambientales y los derivados del propio envejecimiento del organismo.<\/p><p><img decoding=\"async\" class=\"size-full wp-image-8083 aligncenter\" src=\"http:\/\/www.amarintech.com\/wp-content\/uploads\/2021\/04\/Pareja-3ra-Edad.jpg\" alt=\"\" width=\"626\" height=\"417\" srcset=\"https:\/\/amarintech.com\/wp-content\/uploads\/2021\/04\/Pareja-3ra-Edad.jpg 626w, https:\/\/amarintech.com\/wp-content\/uploads\/2021\/04\/Pareja-3ra-Edad-300x200.jpg 300w, https:\/\/amarintech.com\/wp-content\/uploads\/2021\/04\/Pareja-3ra-Edad-16x12.jpg 16w\" sizes=\"(max-width: 626px) 100vw, 626px\" \/><\/p><h2>S\u00edntomas<\/h2><p>La enfermedad se caracteriza por bradiquinesia, rigidez muscular, temblor en reposo y trastornos del equilibrio postural.<\/p><p>Los s\u00edntomas comienzan lentamente, en general, en un lado del cuerpo. Sin embargo, con el avance de la enfermedad puede manifestarse en ambos lados.<\/p><p>El temblor es uno de los s\u00edntomas motores de esta enfermedad y tambi\u00e9n el m\u00e1s conocido. Sin embargo, existen otros s\u00edntomas que en muchas ocasiones son m\u00e1s invalidantes, como son los denominados s\u00edntomas no motores. Entre estos destacan los problemas del sue\u00f1o, la depresi\u00f3n, los trastornos de control de impulsos, o los problemas cognitivos.<\/p><h3>\u00bfA qu\u00e9 se debe?<\/h3><p>Las enfermedades degenerativas se conocen como aquellos padecimientos en los cuales la funci\u00f3n o la estructura de los tejidos u \u00f3rganos afectados empeoran con el transcurso del tiempo. Esto se debe al da\u00f1o en las c\u00e9lulas nerviosas del cerebro que provocan una deficiencia en los niveles de dopamina. La disminuci\u00f3n de este neurotransmisor conlleva a que se produzcan los principales s\u00edntomas motores mencionados anteriormente.<\/p><p><img decoding=\"async\" class=\"aligncenter wp-image-8084\" src=\"http:\/\/www.amarintech.com\/wp-content\/uploads\/2021\/04\/Dopamina-ES.jpg\" alt=\"\" width=\"650\" height=\"454\" srcset=\"\" sizes=\"(max-width: 650px) 100vw, 650px\" data-srcset=\"\" \/><\/p><h3>Tratamiento<\/h3><p>A pesar de todos los avances de la neurolog\u00eda, hoy en d\u00eda se desconoce la etiolog\u00eda o causa de la enfermedad de Parkinson, por lo que tambi\u00e9n se desconoce c\u00f3mo prevenirla. Afecta tanto a hombres como a mujeres, y m\u00e1s del 70 % de las personas diagnosticadas con Parkinson supera los 65 a\u00f1os de edad. Sin embargo, no es una enfermedad exclusivamente de personas de edad avanzada ya que el 30 % de los diagnosticados es menor de 65 a\u00f1os.<\/p><p>Actualmente la enfermedad de Parkinson no tiene cura, pero s\u00ed se puede controlar de forma muy eficaz. Los tratamientos actuales se dirigen \u00fanicamente a mejorar los s\u00edntomas derivados de la p\u00e9rdida y muerte neuronal. Como consecuencia de esto, los afectados por Parkinson deben consumir f\u00e1rmacos antiparkinsonianos de por vida, seg\u00fan la dosis y combinaci\u00f3n de medicamentos que su neur\u00f3logo considere m\u00e1s adecuado para cada caso en particular. En el caso de estad\u00edos muy avanzados de la enfermedad, los problemas a resolver son las fluctuaciones de estado motor y no motor derivadas de la neurodegeneraci\u00f3n progresiva y de la regulaci\u00f3n dopamin\u00e9rgica.<\/p><p>Una de las alternativas cl\u00ednicas m\u00e1s utilizadas para combatir el d\u00e9ficit dopamin\u00e9rgico es precisamente utilizar f\u00e1rmacos agonistas de dicho transmisor -conocidos como agonistas dopamin\u00e9rgicos- como es el caso de la Rotigotina, entre otros, con el objetivo de estimular los receptores correspondientes a la dopamina.<\/p><p>Estos f\u00e1rmacos adem\u00e1s de estimular dichos receptores, tienen actividad sobre otros sistemas neuroqu\u00edmicos, principales responsables de los efectos secundarios o de la mejor\u00eda de s\u00edntomas no motores, como la depresi\u00f3n.<\/p><p>Es importante tener en cuenta que todos los f\u00e1rmacos agonistas dopamin\u00e9rgicos pueden causar efectos secundarios que deben ser informados al neur\u00f3logo de inmediato. Los mismos pueden incluir n\u00e1useas, v\u00f3mitos, estre\u00f1imiento, p\u00e9rdida de apetito, somnolencia, mareos, dolor de cabeza, aumento de peso, hinchaz\u00f3n de extremidades, aumento de la sudoraci\u00f3n, boca seca, falta de energ\u00eda, dolor de articulaciones, visi\u00f3n anormal o latido del coraz\u00f3n irregular.<\/p><h3>Parches transdermales<\/h3><p>La administraci\u00f3n transd\u00e9rmica de agonistas dopamin\u00e9rgicos como la Rotigotina es posible mediante  parches transdermales, los cuales generan una estimulaci\u00f3n dopamin\u00e9rgica continua permitiendo una estimulaci\u00f3n m\u00e1s fisiol\u00f3gica y garantizando niveles estables del f\u00e1rmaco. Desde ya, la concentraci\u00f3n plasm\u00e1tica aumenta a medida que lo hace la dosis, sin importar la modificaci\u00f3n del sitio de aplicaci\u00f3n, el sexo y la edad de los pacientes.<\/p><p>De hecho, los avances que se han conseguido para la Rotigotina transdermal son tan significativos en cuanto a seguridad y eficacia del tratamiento que representan la \u00fanica forma farmac\u00e9utica a trav\u00e9s de la cual se administra dicha droga.<\/p><h3>Ventajas de los parches transdermales de Rotigotina<\/h3><p>El parche de Rotigotina permite restituir la manera de liberar dopamina de forma constante en pacientes con Parkinson. De esta forma, la liberaci\u00f3n del f\u00e1rmaco desde el parche proporciona niveles plasm\u00e1ticos estables y un mejor cumplimiento terap\u00e9utico por parte del paciente.<\/p><p>Asimismo, es importante destacar que la aplicaci\u00f3n transdermal podr\u00eda resultar ventajosa por sobre otras v\u00edas de administraci\u00f3n; por ejemplo las formas orales (ej: comprimidos), en especial cuando la enfermedad de Parkinson en su fase avanzada puede presentar dificultad para tragar; y los parches de Rotigotina se aplican en la piel una vez al d\u00eda; pudi\u00e9ndose inclusive aplicar por un cuidador.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8088 size-large aligncenter\" src=\"http:\/\/www.amarintech.com\/wp-content\/uploads\/2021\/04\/Ventajas-Parches-Espanol.jpg\" alt=\"\" width=\"640\" height=\"562\" srcset=\"\" sizes=\"(max-width: 640px) 100vw, 640px\" data-srcset=\"\" 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Organization declared April 11th as World Parkinson&#8217;s Day, coinciding with the anniversary of the birth of James Parkinson, a British neurologist who, in 1817, discovered what he called &#8216;agitating paralysis&#8217; and which we know today as Parkinson&#8217;s disease.<\/p>","protected":false},"author":6,"featured_media":8099,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8080","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>World Parkinson&#039;s Day - Amarin Technologies<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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