{"id":8729,"date":"2021-11-09T10:12:03","date_gmt":"2021-11-09T10:12:03","guid":{"rendered":"https:\/\/www.amarintech.com\/?p=8729"},"modified":"2021-11-25T15:01:53","modified_gmt":"2021-11-25T15:01:53","slug":"dr-francisco-stefano-the-truth-is-not-always-what-you-believe-but-what-you-find","status":"publish","type":"post","link":"https:\/\/amarintech.com\/es\/dr-francisco-stefano-the-truth-is-not-always-what-you-believe-but-what-you-find\/","title":{"rendered":"Dr. Francisco Stefano: \u201cLa verdad no siempre es la que uno cree, sino la que uno encuentra\u201d"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"8729\" class=\"elementor elementor-8729\">\n\t\t\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-c78867c elementor-section-height-min-height she-header-yes elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-eae-slider=\"71217\" 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class=\"elementor-heading-title elementor-size-default\">Dr. Francisco Stefano: \u201cLa verdad no siempre es la que uno cree, sino la que uno encuentra\u201d<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-62b6c1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-eae-slider=\"76825\" data-id=\"62b6c1f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-97230eb\" data-eae-slider=\"79582\" data-id=\"97230eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-003eebf elementor-widget elementor-widget-spacer\" data-id=\"003eebf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a8f378 elementor-widget elementor-widget-text-editor\" data-id=\"5a8f378\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Un repaso por la evoluci\u00f3n del mercado transdermal en la voz del Dr. Francisco Stefano, nuestro director. Desaf\u00edos de la ciencia y la pasi\u00f3n como protagonista.<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2ccb7bf elementor-widget elementor-widget-spacer\" data-id=\"2ccb7bf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e65dbd elementor-widget elementor-widget-text-editor\" data-id=\"9e65dbd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>El Dr. Francisco Stefano es una de las piezas fundamentales de Amarin y ha sido parte de los primeros desarrollos transdermales en Argentina y Latinoam\u00e9rica. En una entrevista exclusiva nos habla sobre los inicios del desarrollo transdermal en la regi\u00f3n, la fundaci\u00f3n de Amarin y comparte su visi\u00f3n sobre el presente y el futuro de esta forma farmac\u00e9utica.<\/p><p>Un testimonio invaluable donde adem\u00e1s de compartir su vasta experiencia en el sector transdermal, nos abre las puertas de su enriquecedora historia personal.<\/p><p>\u00a1Que la disfrute!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ed374a elementor-widget elementor-widget-text-editor\" data-id=\"0ed374a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>Conociendo al Dr. Francisco Stefano<\/strong><\/h3><p>\u00a0<\/p><p>\u00a0<\/p><p>Le presentamos al Dr. Francisco Stefano. Se gradu\u00f3 como M\u00e9dico en la Universidad de Buenos Aires, becario del Prof Bernardo Houssay en el Instituto de Biolog\u00eda Experimental complet\u00f3 su entrenamiento en Farmacolog\u00eda en el National Institutes of Health (NIH), en Bethesda, Maryland (Estados Unidos) bajo la direcci\u00f3n de Bernard Brodie.<\/p><p>Al regresar al pa\u00eds se incorpor\u00f3 al naciente Instituto de Investigaciones Farmacol\u00f3gicas (ININFA), fundado por el Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) con el objeto de modernizar e  impulsar el desarrollo de las ciencias farmacol\u00f3gicas en la Argentina. Dirigi\u00f3 este Instituto desde 1975 a 1986.<\/p><p>El ININFA cumpli\u00f3 una importante labor en el aggiornamiento  de la farmacolog\u00eda en el pa\u00eds. Entre los logros cient\u00edficos alcanzados puede se\u00f1alarse el hallazgo de los receptores presin\u00e1pticos. Dicha investigaci\u00f3n fue calificada por el British Pharmacological Journal, una de las m\u00e1s reconocidas publicaciones de farmacolog\u00eda <em>\u201ccomo uno de los cincuenta trabajos m\u00e1s importantes que ellos hayan publicado\u201d.<\/em>.<\/p><p>En 1986 dej\u00f3 la investigaci\u00f3n b\u00e1sica para trabajar en la industria incorpor\u00e1ndose a un laboratorio nacional donde mont\u00f3 un sector de I+D dedicado inicialmente a estudios farmacocin\u00e9ticos y que fu\u00e9 derivando hacia el desarrollo de formulaciones que facilitaran la absorci\u00f3n con baja biodisponibilidad por v\u00eda oral. Estos estudios dieron base al desarrollo de los productos  transdermales.<\/p><p>En la actualidad es el Director de Amarin. Adem\u00e1s es profesor em\u00e9rito en el Departamento de Farmacolog\u00eda de la Facultad de Medicina de la Universidad de Buenos Aires y ense\u00f1a en diversas universidades privadas. En su carrera public\u00f3 m\u00e1s de 100 trabajos cient\u00edficos en revistas internacionales y cuenta con varias patentes en el \u00e1rea transdermal.<\/p><h3>\u00a0<\/h3><h3><strong>El Dr. Stefano en su faceta m\u00e1s personal<\/strong><\/h3><p>Una carrera tan prol\u00edfica no fue casualidad. Fue fruto de trabajo incansable y una serie de aprendizajes de vida como por ejemplo:<\/p><ul><li><strong>Su cercan\u00eda a tres premios Nobel: <\/strong>Fue becario del Dr. Bernardo Houssay, tuvo contacto frecuente con Federico Leloir y m\u00e1s tarde en el NIH con Julius Axelrod. Este ha sido un factor importante para convertirse en el cient\u00edfico que es, uno que no se enamora de sus teor\u00edas sino que trabaja sin descanso en busca de la verdad. As\u00ed define al trabajo cient\u00edfico:<\/li><\/ul><p style=\"text-align: center;\"><strong>\u201cUno tiene que hacer el trabajo cient\u00edfico y olvidarse del orgullo. <br \/><\/strong><strong>Que la verdad no siempre es la que uno cree, <br \/><\/strong><strong>sino la que uno encuentra<\/strong><strong> y<\/strong><strong>\u00a0el resultado de todo <br \/>experimento <\/strong><strong>es la \u00fanica verdad que existe\u201d.<\/strong><\/p><p style=\"text-align: center;\">Dr. Francisco Stefano\u00a0<\/p><p>\u00a0<\/p><ul><li><strong>Estimular el pensamiento cr\u00edtico dentro de su equipo: <\/strong>Stefano es una persona que pone en valor al grupo humano con el que trabaja y la opini\u00f3n de cada uno de ellos. Para dar ese espacio dice que <em>\u201cUno tiene que decir qu\u00e9 hay que hacer y escuchar por qu\u00e9 no lo van a hacer. Entonces vos ah\u00ed empez\u00e1s a hacer que esa persona tenga ganas de pensar cosas distintas. Porque si cada cosa que le ped\u00eds y no est\u00e1 de acuerdo, vos le exig\u00eds y le dec\u00eds \u00b4No, olvidate, hac\u00e9 como yo te dije. <\/em><em>Es as\u00ed.\u00b4 Ah\u00ed empez\u00e1s a cortar alas\u201d. <\/em><\/li><\/ul><p><em>\u00a0<\/em><\/p><ul><li><strong>Cultivar una mente enciclop\u00e9dica:<\/strong> \u00c9l asume que esta apertura de mente se debe a lo que llama una <em>\u201cmente enciclop\u00e9dica\u201d<\/em> que forj\u00f3 gracias a horas y horas de diversas lecturas y la bendici\u00f3n de tener una madre muy culta. En este sentido acota: <em>\u201dSi uno tiene una mente abierta entiende de todo, entonces es f\u00e1cil preguntar a las cosas por qu\u00e9 son c\u00f3mo son. Eso es ciencia, eso es investigaci\u00f3n\u201d. <\/em><em>Eso es ciencia, eso es investigaci\u00f3n\u201d.<\/em><\/li><\/ul><h3>\u00a0<\/h3><h3><strong>Los inicios del sistema transdermal en Am\u00e9rica del Sur<\/strong><\/h3><p>Como le contamos en la introducci\u00f3n, a partir de mediados de los ochenta \u00e9l se ha dedicado al sector transdermal. Cuando le consultamos sobre c\u00f3mo fueron sus inicios en la investigaci\u00f3n en esta \u00e1rea nos comenta: <em>\u201cEn 1986, yo trabajaba en la Facultad de Farmacia y en el CONICET y decid\u00ed cambiar de actividad. Pas\u00e9 de la docencia y la investigaci\u00f3n b\u00e1sica a lo que ser\u00eda trabajar en la industria farmac\u00e9utica\u201d.<\/em> De este modo, se sum\u00f3 como Director del Departamento de Investigaci\u00f3n y Desarrollo de Laboratorios Beta S.A. Donde comenz\u00f3 trabajando en proyectos relacionados con la optimizaci\u00f3n de la absorci\u00f3n de medicamentos administrados por v\u00eda oral.<\/p><p>Recuerda que, a finales del a\u00f1o 86, la direcci\u00f3n de Laboratorios Beta lo invit\u00f3 a trabajar en un novedoso sistema: <em>\u201dMientras estaba haciendo esos estudios, apareci\u00f3 una t\u00e9cnica muy innovadora: la administraci\u00f3n de medicamentos con efectos sist\u00e9micos a trav\u00e9s de la piel. Lo que llamamos sistemas transdermales\u201d.<\/em><\/p><p>Hasta ese momento solo hab\u00eda dos o tres transdermales destinados al mareo y la menopausia, los cuales hab\u00edan sido desarrollados por un qu\u00edmico uruguayo en California.  El Dr. Stefano relata c\u00f3mo fueron los primeros experimentos transdermales de los que particip\u00f3: <em>\u201cArm\u00e9 un grupo peque\u00f1o de colaboradores, de los cuales, dos proven\u00edan del laboratorio de investigaciones donde yo hab\u00eda estado desarrollando mis actividades. As\u00ed comenzamos a trabajar, de forma muy precaria y aprender lo que es un sistema transdermal, algo completamente nuevo\u201d.<\/em><\/p><h3>\u00a0<\/h3><h3><strong>De Argentina al mundo<\/strong><\/h3><p>Todo ese esfuerzo y las constantes ganas de generar nuevos productos orientados a mejorar la vida de las personas no tardaron en dar sus frutos: <em>\u201cTuvimos la suerte o la oportunidad y logramos desarrollar el primer transdermal que duraba 7 d\u00edas despu\u00e9s de su aplicaci\u00f3n. El cual era para el tratamiento de la menopausia\u201d.<\/em><\/p><p>El producto se lanz\u00f3 en Argentina y los laboratorios American Home compraron la licencia para toda Latinoam\u00e9rica. Hab\u00eda comenzado el proceso de expansi\u00f3n y el Dr. Stefano rememora c\u00f3mo era la producci\u00f3n: <em>\u201cTrabaj\u00e1bamos en una peque\u00f1a f\u00e1brica en Lan\u00fas, donde se manufacturaba el producto y comenz\u00f3 a exportarse a toda Latinoam\u00e9rica\u201d.\u00a0 <\/em><\/p><p>El excelente desempe\u00f1o del equipo comenz\u00f3 a llamar la atenci\u00f3n. As\u00ed fue como poco despu\u00e9s de un Congreso en Niza (Francia), Stefano fue entrevistado por el due\u00f1o de un laboratorio extranjero al que le interesaban los trabajos que estaba desarrollando Beta S.A. En referencia a esta etapa, Stefano relata:<em> \u201dEntonces, comenz\u00f3 las negociaciones con Beta y compr\u00f3 el know how para la fabricaci\u00f3n del transdermal. Realiz\u00f3 un alquiler permanente, creo que por diez a\u00f1os, del piso donde trabajaba la gente que hac\u00eda transdermales, entre los que me encontraba yo. Ah\u00ed pasamos a trabajar para una empresa inglesa que se llamaba Ethical\u201d. <\/em><em>\u00a0<\/em><\/p><p>\u00a0<\/p><h3><strong>El nacimiento de Amarin<\/strong><\/h3><p>En 2001, con el desplome de la econom\u00eda argentina la empresa inglesa decide dejar el pa\u00eds. Entonces, el Doctor junto a dos empleados m\u00e1s de la sucursal argentina, Sergio Lucero y Roberto Gabach, compraron las acciones de la empresa y as\u00ed comenz\u00f3 Amarin Argentina.<\/p><p>Ya han pasado 20 a\u00f1os desde que Amarin vio la luz. Al consultarle a Stefano sobre c\u00f3mo fue la evoluci\u00f3n de la compa\u00f1\u00eda en estas d\u00e9cadas indica: <em>\u201cAmarin todav\u00eda conserva el n\u00facleo inicial, ya que tres de los gerentes actuales entraron como empleados rasos en Beta en el siglo pasado podemos decir. Fue aprendizaje y la industria farmac\u00e9utica ha cambiado mucho en estos a\u00f1os\u201d.<\/em><\/p><p>Y cuando habla de aprendizaje el Doctor refiere a diversos aspectos: <em>\u201cLo que hicieron los actuales gerentes es estudiar, ponerse siempre al tanto y aprender hacia d\u00f3nde iba la industria. Las regulaciones nuevas. El mayor cuidado que existe hoy con respecto a hace veinte a\u00f1os en cuanto a sustancias que pueden entrar en el proceso por accidente. C\u00f3mo es un trabajo con calidad garantizada\u201d. <\/em><\/p><p><em>\u00a0<\/em><\/p><p>Es importante destacar que el personal t\u00e9cnico superior no hizo cursos especiales sino que se form\u00f3 a trav\u00e9s de la experiencia dentro y fuera del laboratorio. En este aspecto destaca:<em> \u201cCada vez que ten\u00edamos una entrevista o cuando \u00edbamos al exterior a un Congreso o a discutir un producto escuch\u00e1bamos mucho las opiniones de los socios y del personal t\u00e9cnico-cient\u00edfico de los laboratorios. \u00c9ramos esponjas\u201d.<\/em><\/p><p>\u00a0<\/p><p style=\"text-align: center;\"><em><strong>Hasta el a\u00f1o 2015 el <\/strong><strong>70 por ciento<\/strong><strong> del trabajo <br \/><\/strong><\/em><em><strong>de la empresa se enfoc\u00f3 en desarrollar y vender la idea,<br \/><\/strong><\/em><em><strong>la patente o la licencia de los productos que creaba. <\/strong><\/em><\/p><p style=\"text-align: center;\">\u00a0Dr. Francisco Stefano\u00a0<\/p><p>\u00a0<\/p><p>En la actualidad, no solo se desarrolla sino que cada vez se fabrican m\u00e1s de esos medicamentos. En este sentido el Doctor agrega: <em>\u201cTenemos una unidad productora que puede ser admitida por las autoridades regulatorias extranjeras. Nunca hemos tenido un problema\u201d.<\/em><\/p><p><em>\u00a0<\/em><\/p><p>Por eso cuando le consultamos sobre los valores principales de Amarin remarca: <em>\u201cEs una empresa que es confiable y que siempre hace todos los esfuerzos posibles para obtener un resultado\u201d.<\/em><\/p><p><em>\u00a0<\/em><\/p><h3><strong>Tecnolog\u00eda Transdermal: Presente y futuro <\/strong><\/h3><p>Al preguntarle sobre c\u00f3mo ve a la tecnolog\u00eda transdermal en el presente, Stefano destaca que la misma se encuentra en una etapa madura y que est\u00e1 lista para una segunda fase de crecimiento.<\/p><p>Pero, \u00bfcu\u00e1les son las nuevas tecnolog\u00edas que considera generar\u00e1n el salto hacia esta segunda fase?. Seg\u00fan su interpretaci\u00f3n esto se podr\u00eda dar gracias al desarrollo de las nanoestructuras. Al respecto ampl\u00eda: <em>\u201cHoy en d\u00eda hay muchos medicamentos que tienen mol\u00e9culas grandes que atraviesan con dificultad por su tama\u00f1o las barreras tipo peel que son la base de la administraci\u00f3n transdermal.(...) Por eso si uno puede lograr que esas mol\u00e9culas permeen la piel, es probable que se puedan generar los sistemas transdermales del siglo 21\u201d.<\/em><\/p><p>Tambi\u00e9n le preguntamos sobre dos tecnolog\u00edas que cada vez van adquiriendo m\u00e1s difusi\u00f3n, aunque a\u00fan est\u00e9n en plena etapa de desarrollo: las microagujas y la impresi\u00f3n 3D.<\/p><p>Respecto a las microagujas considera que<em> \u201cva a funcionar bien en alg\u00fan caso espec\u00edfico y le van a encontrar la pareja, es decir, la droga para micro-atravesar la piel y hacer m\u00e1s f\u00e1cil la entrada a la piel. Nuevamente,<\/em> \u2014aclara\u2014<em> no veo que vaya a haber 4, 5 o 6 productos de microagujas\u201d.<\/em><\/p><p><em>\u00a0<\/em><\/p><p>On the other hand, he warns that although he has not delved into <a href=\"https:\/\/www.amarintech.com\/es\/3d-printer-the-future-of-personalized-medicine\/\">impresi\u00f3n 3D<\/a>\u00a0, but anyway he shares his opinion on the subject : <em>\u201cYo no lo veo para un sistema en serie, por su baja producci\u00f3n, y tampoco lo veo para que alguien lo tenga en su casa para hacerse una microaguja cada tantos d\u00edas\u201d.<\/em><\/p><p><em>\u00a0<\/em><\/p><h3><strong>En resumen,<\/strong><\/h3><p>Este valioso testimonio nos brinda no solo un recorrido por la evoluci\u00f3n del sistema transdermal, sino que nos ayuda a ver la importancia que tiene la humanizaci\u00f3n de la ciencia en los resultados. Valor que sin duda el Doctor ha sabido imprimir en el esp\u00edritu de Amarin que, como \u00e9l dice, combina la confiabilidad y la inagotable persistencia para conseguir el resultado que buscan nuestros socios comerciales.<\/p><p>Would you like to tell us about your project? 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Desaf\u00edos de la ciencia y la pasi\u00f3n como protagonista.<\/p>","protected":false},"author":6,"featured_media":8730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dr. Francisco Stefano: &quot;The truth is not always what you believe, but what you find&quot;<\/title>\n<meta name=\"description\" content=\"A review of the evolution of the transdermal market in the voice of Dr. Francisco Stefano, our director. 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