{"id":8984,"date":"2022-05-31T12:37:12","date_gmt":"2022-05-31T12:37:12","guid":{"rendered":"https:\/\/amarintech.com\/?p=8984"},"modified":"2022-05-31T12:37:12","modified_gmt":"2022-05-31T12:37:12","slug":"dementia-current-events-and-projections","status":"publish","type":"post","link":"https:\/\/amarintech.com\/es\/dementia-current-events-and-projections\/","title":{"rendered":"Dementia: current events and projections"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8984\" class=\"elementor elementor-8984\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c78867c elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c78867c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-387f22c\" data-id=\"387f22c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b3b76c9 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default\" data-id=\"b3b76c9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-aed56c4\" data-id=\"aed56c4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-22fcc07 elementor-widget elementor-widget-image\" data-id=\"22fcc07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/amarintech.com\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2000\" height=\"638\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGO.avif\" class=\"attachment-full size-full wp-image-5849\" alt=\"\" srcset=\"https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGO.avif 2000w, https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGO-300x96.avif 300w, https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGO-1024x327.avif 1024w, https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGO-768x245.avif 768w, https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGO-1536x490.avif 1536w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-442b119\" data-id=\"442b119\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0e68f5c elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"0e68f5c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_bottom&quot;:&quot;mountains&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" opacity=\"0.33\" d=\"M473,67.3c-203.9,88.3-263.1-34-320.3,0C66,119.1,0,59.7,0,59.7V0h1000v59.7 c0,0-62.1,26.1-94.9,29.3c-32.8,3.3-62.8-12.3-75.8-22.1C806,49.6,745.3,8.7,694.9,4.7S492.4,59,473,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" opacity=\"0.66\" d=\"M734,67.3c-45.5,0-77.2-23.2-129.1-39.1c-28.6-8.7-150.3-10.1-254,39.1 s-91.7-34.4-149.2,0C115.7,118.3,0,39.8,0,39.8V0h1000v36.5c0,0-28.2-18.5-92.1-18.5C810.2,18.1,775.7,67.3,734,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M766.1,28.9c-200-57.5-266,65.5-395.1,19.5C242,1.8,242,5.4,184.8,20.6C128,35.8,132.3,44.9,89.9,52.5C28.6,63.7,0,0,0,0 h1000c0,0-9.9,40.9-83.6,48.1S829.6,47,766.1,28.9z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c82bb91\" data-id=\"c82bb91\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e6195d elementor-widget elementor-widget-heading\" data-id=\"2e6195d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Dementia: current events and projections<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-731434c elementor-widget elementor-widget-text-editor\" data-id=\"731434c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Germ\u00e1n M\u00fcller\u00a0<\/strong><strong>\u2013\u00a0<\/strong>Business Development Manager<\/p><div id=\"gtx-trans\" style=\"position: absolute; left: -21px; top: -10px;\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c9ded8a\" data-id=\"c9ded8a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62b6c1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"62b6c1f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-97230eb\" data-id=\"97230eb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-003eebf elementor-widget elementor-widget-spacer\" data-id=\"003eebf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e564a3 elementor-widget elementor-widget-text-editor\" data-id=\"0e564a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\"><b>We tell you what dementia is, and how it has become one of the main causes of disability and dependence among the elderly. We also review current pharmacological treatments.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44be759 elementor-widget elementor-widget-text-editor\" data-id=\"44be759\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">According to the WHO, dementia is a syndrome characterized by deterioration of cognitive function beyond what might be considered a consequence of normal aging. Dementia affects memory, thinking, orientation, comprehension, calculation, learning ability, language, and judgment. Meanwhile, consciousness is not affected.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p><p class=\"p1\">Impairment of cognitive function is often accompanied and sometimes preceded, by impairment of emotional control, social behavior, or motivation.<\/p><p class=\"p1\">Considering that dementia is one of the leading causes of disability and dependence among older people worldwide, it can be overwhelming not only for those who suffer from it but also for their caregivers and family members. There is often a lack of awareness and understanding of dementia. This can cause stigmatization and pose a barrier to people seeking diagnostic and care services on time. The impact of dementia on caregivers, family, and society can be physical, psychological, social, and economic.<\/p><h3><b>Types of Dementia<\/b><\/h3><p class=\"p1\">The forms of dementia are multiple and diverse, with the most common types being so-called neurodegenerative diseases. In these conditions brain, cells stop functioning or die. These include<\/p><ul class=\"ul1\"><li class=\"li4\"><b>Alzheimer&#8217;s disease: <\/b>the most common form of dementia among older people. This condition causes plaque and tangles in the brain caused by the abnormal growth of different proteins. The beta-amyloid protein builds up and forms plaque between your brain cells. There is also a loss of connection between nerve cells in the brain. We have gone into more detail in <a href=\"https:\/\/amarintech.com\/alzheimers-month\/\"><span class=\"s2\">this<\/span><\/a> article.<\/li><li class=\"li4\"><b>Dementia with Lewy bodies:<\/b> Causes movement symptoms along with dementia. Lewy bodies are abnormal deposits of protein in the brain.<\/li><li class=\"li1\"><b>Frontotemporal disorders:<\/b> This is a group of diseases characterized by neuronal degeneration and disruption of their connections in the frontal and temporal lobes of the brain. These areas of the brain are usually associated with personality, behavior, and language.<\/li><\/ul><p class=\"p3\"><b>\u00a0<\/b><\/p><h3><b>Dementia Rates and Projections<\/b><\/h3><p class=\"p1\">About 50 million people worldwide were affected by dementia in 2020, about 60% of whom live in low- and middle-income countries. About 10 million new cases are reported each year, implying a new case every 3.2 seconds. The total number of people with dementia is expected to reach 82 million by 2030 and 152 million by 2050. It is estimated that between 5% and 8% of the general population aged 60 years or older suffer from dementia at any given time.<\/p><p class=\"p1\">As already indicated, a significant portion of this increase can be attributed to the fact that in low- and middle-income countries the number of people with dementia will tend to increase more and more. The<span class=\"Apple-converted-space\">\u00a0 <\/span>fastest growth of the elderly population is occurring in China, India, and Southeast Asian countries. It is estimated that the share of this segment will reach 71% of the total by 2050.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5dd901b elementor-widget elementor-widget-image\" data-id=\"5dd901b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2022\/05\/amarin1.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d09ac84 elementor-widget elementor-widget-text-editor\" data-id=\"d09ac84\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p class=\"p1\">Currently, the population most affected are those over 65 years of age and, globally, 65% of the cases are women. However, there is growing awareness that the disease can begin 10 to 20 years before diagnosis.<br \/><br \/><\/p><h3><b>Pharmacological treatment of dementia associated with Alzheimer&#8217;s disease<\/b><\/h3><p class=\"p1\">So far, no treatment can cure dementia or reverse its progressive progression. However,<span class=\"Apple-converted-space\">\u00a0 <\/span>numerous interventions can be offered to support and improve the lives of people with dementia, their caregivers, and their families.<\/p><p class=\"p1\">When it comes to medications, there are two types of alternatives to treat the symptoms of dementia. The first group is<b> cholinesterase inhibitors.<\/b> This group includes donepezil (Aricept\u00ae), rivastigmine (Exelon\u00ae), and galantamine (Razadyne\u00ae). These act by increasing the levels of a chemical messenger involved in memory and reasoning, and can help reduce or control cognitive and behavioral symptoms.<\/p><p class=\"p1\">While, in more advanced stages of the disease, memantine (Namenda\u00ae) is prescribed, which acts by regulating glutamate activity and whose main effect is to reduce symptoms. This may allow some people to maintain certain daily functions for a little longer than without the drug.<\/p><h3><b>The impact of generics and current world market distribution<\/b><\/h3><p class=\"p1\">It is important to note that the market for dementia drugs has undergone a process of generic penetration over the last decade. This has logically reduced the cost of access to this type of medicine, bringing the global invoicing from USD 8.5 MM in 2010 to about USD 2.8 MM in 2020. <span class=\"Apple-converted-space\">\u00a0<\/span><\/p><p class=\"p1\">At the regional level, the sharpest declines have occurred in the United States and Europe, where the global market fell from USD 6.843 million to USD 1.331 million for the same period. On the other hand, APAC (Asia-Pacific), the region that accounts for the majority of sales for these molecules worldwide (42% of the market in 2020), has only seen an invoicing contraction of 13% over the last decade.<\/p><p class=\"p1\">As indicated above, this overall invoicing retraction is only due to the decline in unit selling price. The volume has increased steadily over the same period, reaching 44% more daily treatments in the last decade, as we can see in the following table.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2912c7e elementor-widget elementor-widget-image\" data-id=\"2912c7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2022\/05\/amarin2.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e148fe0 elementor-widget elementor-widget-text-editor\" data-id=\"e148fe0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">As regards the distribution of the world market by molecule, two drugs share almost equally 80% of the total volume of treatments: Donepezil and Memantine. Rivastigmine accounts for just under 10%. However, thanks to its competitive advantages (as it is the only one so far available in patches on the market), it accounts for 20% of the worldwide invoicing for the segment under evaluation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1780379 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1780379\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b11b44b\" data-id=\"b11b44b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a9f6e9 elementor-widget elementor-widget-image\" data-id=\"8a9f6e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2022\/05\/amarin3.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d257fda\" data-id=\"d257fda\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-400bf86 elementor-widget elementor-widget-image\" data-id=\"400bf86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2022\/05\/amarin4.jpg\" title=\"\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-025643d elementor-widget elementor-widget-text-editor\" data-id=\"025643d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3><b><br \/>New pharmacological treatments to treat dementia associated with Alzheimer&#8217;s disease<\/b><\/h3><p class=\"p3\">We can mention that some new developments have recently appeared in the drug market for the treatment of Alzheimer&#8217;s disease, which are listed below:<\/p><p class=\"p3\"><b>Aducanumab: <\/b>in mid-2021, the FDA issued an &#8220;accelerated approval&#8221; for the only immune therapy or modifying drug that would address the underlying causes of the disease. As it would help reduce amyloid deposits in the brain, it could help slow the progression of Alzheimer&#8217;s disease.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p><p class=\"p3\">However, this approval has generated great controversy in the scientific community. The European Medicines Agency (EMA) did not authorize the commercialization of aducanumab, because they consider that the benefit\/risk ratio is negative.<\/p><p class=\"p3\"><b>Donepecilo Patch:<\/b> in March 2022, the FDA approved Corium&#8217;s Adlarity\u00ae 7-day patch for the treatment of patients with mild, moderate or severe dementia of the Alzheimer&#8217;s type. The first donepezil patch approved worldwide (November 2021) was from Icure\/Celltrion in South Korea. It is a 3-4 day patch branded as Donerion\u00ae.<\/p><p class=\"p3\"><b>Rivastigmine Multiday:<\/b> in May 2020 Luye Pharma AG announced that its Rivastigmine multiday patch (Rivalif\u00ae) was under evaluation by the European Medicines Agency.<\/p><p class=\"p4\">In conclusion, it is important to note that there are currently numerous projects in various stages of development. Among these, two monoclonal antibodies stand out: Donanemab (Eli Lilly) and Gantenerumab (Roche). However, it will be several years before an eventual market launch.<\/p><h3><b>Development of generic patches for the treatment of dementia: a business opportunity<\/b><\/h3><p class=\"p3\">Global population growth and the steady increase in life expectancy mean that dementia will continue to be one of the most pressing global health issues.<\/p><p class=\"p3\">The medical community and the pharmaceutical industry continue to search for the long-awaited development of a mechanism to cure dementia associated with Alzheimer&#8217;s disease. In the meantime, existing therapies that delay the progression of dementia and the onset of symptoms will maintain their relevance in allowing the patient to benefit from the treatment of Alzheimer&#8217;s disease.<\/p><p class=\"p3\">Similarly, the current alternatives can continue to evolve into more complex pharmaceutical forms that provide benefits to both the patient and the families of affected individuals and their caregivers. This will be incentive enough to develop transdermal patches to achieve this goal.<\/p><p class=\"p3\">In Amarin, you will find a <a href=\"https:\/\/www.linkedin.com\/posts\/amarin-technologies-s-a-_amarintech-trustamarin-ourvalues-activity-6919996340609462272-RU_3?utm_source=linkedin_share&amp;utm_medium=member_desktop_web\"><span class=\"s2\">professional partner<\/span><\/a> with more than 30 years of experience. We have the know-how to make your transdermal project possible and a team with flexibility, transparency and commitment.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p><p class=\"p3\"><b>Sources:<\/b><\/p><ol class=\"ol1\"><li class=\"li6\"><span class=\"s4\">FDA. FDA Grants Accelerated Approval for Alzheimer\u2019s Drug (June 07, 2021). <a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-drug\"><span class=\"s5\">https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-drug<\/span><\/a><\/span><\/li><li class=\"li3\">AMARISTA, F\u00e9lix Jos\u00e9.\u00a0Demencia.<i>\u00a0Gac M\u00e9d Caracas<\/i>\u00a0[online]. 2002, vol.110, n.3<\/li><li class=\"li6\"><span class=\"s4\">Alzheimer &#8216;s Disease International. <i>\u201cDemetia Statistics\u201d.<\/i> <a href=\"https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/\"><span class=\"s5\">https:\/\/www.alzint.org\/about\/dementia-facts-figures\/dementia-statistics\/<\/span><\/a><\/span><\/li><li class=\"li6\"><span class=\"s4\">Organizaci\u00f3n mundial de la Salud \u201cDemencia\u201d <a href=\"https:\/\/www.who.int\/es\/news-room\/fact-sheets\/detail\/dementia\"><span class=\"s5\">https:\/\/www.who.int\/es\/news-room\/fact-sheets\/detail\/dementia<\/span><\/a><\/span><\/li><li class=\"li6\"><span class=\"s4\">Naciones Unidas \u201cPoblaci\u00f3n\u201d <a href=\"https:\/\/www.un.org\/es\/global-issues\/population\"><span class=\"s5\">https:\/\/www.un.org\/es\/global-issues\/population<\/span><\/a><\/span><\/li><li class=\"li7\">National Institute on Aging. <i>\u201cHow Is Alzheimer&#8217;s Disease Treated?\u201d <\/i>(Noviembre 15, 2021). <a href=\"https:\/\/www.nia.nih.gov\/health\/how-alzheimers-disease-treated\"><span class=\"s2\">https:\/\/www.nia.nih.gov\/health\/how-alzheimers-disease-treated<\/span><\/a><span class=\"Apple-converted-space\">\u00a0<\/span><\/li><li class=\"li7\">R. Re\u00f1\u00e9a, J. Ricartb, B. Hern\u00e1ndezb, en representaci\u00f3n de los investigadores del Estudio Experience. <i>\u201cExperiencia de uso y satisfacci\u00f3n con rivastigmina transd\u00e9rmica en cuidadores de pacientes con enfermedad de Alzheimer de leve a moderada previamente tratados con rivastigmina oral a dosis altas\u201d.<\/i> <a href=\"https:\/\/www.elsevier.es\/es-revista-neurologia-295-articulo-experiencia-uso-satisfaccion-con-rivastigmina-S0213485313000571\"><span class=\"s2\">https:\/\/www.elsevier.es\/es-revista-neurologia-295-articulo-experiencia-uso-satisfaccion-con-rivastigmina-S0213485313000571<\/span><\/a><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-677db80 elementor-widget elementor-widget-spacer\" data-id=\"677db80\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div 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data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a1925e7\" data-id=\"a1925e7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-afb4c3b elementor-widget elementor-widget-heading\" data-id=\"afb4c3b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.cuervoestudio.com.ar\/\">Copyright \u00a92021 Amarin Technologies \nTodos los derechos reservados - Desarrollo by <u>Cuervo estudio<\/u><\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3ebecc6\" data-id=\"3ebecc6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>We tell you what dementia is, and how it has become one of the main causes of disability and dependence among the elderly. We also review current pharmacological treatments.<\/p>","protected":false},"author":4,"featured_media":8986,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[],"class_list":["post-8984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-and-society"],"_links":{"self":[{"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/posts\/8984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/comments?post=8984"}],"version-history":[{"count":0,"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/posts\/8984\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amarintech.com\/es\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/media?parent=8984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/categories?post=8984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amarintech.com\/es\/wp-json\/wp\/v2\/tags?post=8984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}