{"id":9068,"date":"2022-07-28T18:35:53","date_gmt":"2022-07-28T18:35:53","guid":{"rendered":"https:\/\/www.amarintech.com\/?p=9068"},"modified":"2022-07-28T20:57:03","modified_gmt":"2022-07-28T20:57:03","slug":"oral-thin-filmotf","status":"publish","type":"post","link":"https:\/\/amarintech.com\/es\/oral-thin-filmotf\/","title":{"rendered":"Oral Thin Film(OTF)"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9068\" class=\"elementor elementor-9068\">\n\t\t\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-c78867c elementor-section-height-min-height she-header-yes elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c78867c\" data-element_type=\"section\" 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d=\"M473,67.3c-203.9,88.3-263.1-34-320.3,0C66,119.1,0,59.7,0,59.7V0h1000v59.7 c0,0-62.1,26.1-94.9,29.3c-32.8,3.3-62.8-12.3-75.8-22.1C806,49.6,745.3,8.7,694.9,4.7S492.4,59,473,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" opacity=\"0.66\" d=\"M734,67.3c-45.5,0-77.2-23.2-129.1-39.1c-28.6-8.7-150.3-10.1-254,39.1 s-91.7-34.4-149.2,0C115.7,118.3,0,39.8,0,39.8V0h1000v36.5c0,0-28.2-18.5-92.1-18.5C810.2,18.1,775.7,67.3,734,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M766.1,28.9c-200-57.5-266,65.5-395.1,19.5C242,1.8,242,5.4,184.8,20.6C128,35.8,132.3,44.9,89.9,52.5C28.6,63.7,0,0,0,0 h1000c0,0-9.9,40.9-83.6,48.1S829.6,47,766.1,28.9z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c82bb91\" data-id=\"c82bb91\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e6195d elementor-widget elementor-widget-heading\" data-id=\"2e6195d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Oral Thin Film(OTF)<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f45fc6c elementor-widget elementor-widget-text-editor\" data-id=\"f45fc6c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Mailen Ag\u00fcero \u2013\u00a0<\/strong>Analista de Desarrollo de Negocios<br \/><strong>Francisco Stefano \u2013\u00a0<\/strong>Director<\/p><div id=\"gtx-trans\" style=\"position: absolute; left: 356px; top: -9px;\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c9ded8a\" data-id=\"c9ded8a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-62b6c1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"62b6c1f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-97230eb\" data-id=\"97230eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-003eebf elementor-widget elementor-widget-spacer\" data-id=\"003eebf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e564a3 elementor-widget elementor-widget-text-editor\" data-id=\"0e564a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Un oral thin film(OTF) es un film muy delgado compuesto por una matriz polim\u00e9rica mono o multicapa que se aplica en la boca.<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44be759 elementor-widget elementor-widget-text-editor\" data-id=\"44be759\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La mucosa oral posee una permeabilidad intermedia entre la permebilidad de la mucosa intestinal y la permeabilidadde la piel. Dependiendo de la mol\u00e9cula en consideraci\u00f3n la permeabilid la trav\u00e9s de la mucosa oral puede ser entre 4 a 4000 veces mas alta que en la piel.\u00a0<\/p><p>\u00a0<\/p><p>A estas diferencias se deben agregar otros dos factores que mejoran la biodisponibilidad del f\u00e1rmaco administrado. El alto flujo sangu\u00edneo que arrastra r\u00e1pidamente al f\u00e1rmaco manteniendo una alta diferencia de concentraci\u00f3n a trav\u00e9s de la barrera impuesta por la mucosa oral y adem\u00e1s se evita el metabolismo de primer paso.<\/p><p>\u00a0<\/p><p>Los OTF suelen ser pol\u00edmeros solubles a base de agua dise\u00f1ados para administrar f\u00e1rmacos de manera r\u00e1pida y sistem\u00e1tica. Se colocan sobre o debajo de la lengua y son inmediatamente absorbidos por la mucosa bucal y el principio activo es transportado directamente al torrente sangu\u00edneo.<\/p><p>\u00a0<\/p><p>El primer OTF recetado fue Zuplenz (Ondansetron HCl, 4-8 mg) y fue aprobado en 2010. Suboxon (buprenorfina y naloxan) lo sigui\u00f3 r\u00e1pidamente como el segundo aprobado.s<\/p><p>\u00a0<\/p><p>Seg\u00fan el candidato a f\u00e1rmaco y la indicaci\u00f3n espec\u00edfica, OTF se puede formular como:<\/p><ul><li><strong><em>Film bucodispersables<\/em><\/strong> que funcionan como comprimidos convencionales. En este caso, el OTF se disuelve en segundos en la boca y la sustancia farmacol\u00f3gica se traga junto con la saliva y sigue el mismo camino que una tableta.<\/li><li><strong><em> Film transmucoso<\/em><\/strong> en la que el principio activo entra directamente en la circulaci\u00f3n sist\u00e9mica a trav\u00e9s de la mucosa bucal, evitando el efecto de primer paso hep\u00e1tico.<\/li><\/ul><p>\u00a0<\/p><h2><strong><em>Ventajas y limitaciones<\/em><\/strong><\/h2><p>Los OTF tienen muchas ventajas sobre otras formas de dosificaci\u00f3n s\u00f3lidas, como flexibilidad y mayor eficacia de la API.  Para los pacientes geri\u00e1tricos y pedi\u00e1tricos, que tienen dificultad para masticar o tragar las formas farmac\u00e9uticas s\u00f3lidas y se niegan a tomar estas formas farmac\u00e9uticas por miedo a la asfixia, los OTF son una alternativa preferible. La disoluci\u00f3n\/desintegraci\u00f3n r\u00e1pida de los sistemas de administraci\u00f3n de f\u00e1rmacos OTF es una alternativa preferible en pacientes con miedo a la asfixia. Cuando se colocan en la lengua, los OTF se humedecen inmediatamente con saliva. Como resultado, se disuelven para liberar el f\u00e1rmaco para absorci\u00f3n sist\u00e9mica y\/o local.<\/p><p>\u00a0<\/p><p>Sin embargo, esta forma farmac\u00e9utica cuenta con algunas limitaciones.<\/p><ul><li>No es adecuado para medicamentos que causan irritaci\u00f3n en el pH oral y no son duraderos.<\/li><li>Es higrosc\u00f3pico por naturaleza. Por esta raz\u00f3n, causa dificultades para la protecci\u00f3n a largo plazo.<\/li><li>Requiere equipo especial para el embalaje.<\/li><\/ul><p>\u00a0<\/p><div id=\"gtx-trans\" style=\"position: absolute; left: -34px; top: 1079px;\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-inner-section elementor-element elementor-element-1780379 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1780379\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-d257fda\" data-id=\"d257fda\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div 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elementor-element-d24a003 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default\" data-id=\"d24a003\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a1925e7\" data-id=\"a1925e7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-afb4c3b elementor-widget elementor-widget-heading\" data-id=\"afb4c3b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.cuervoestudio.com.ar\/\">Copyright \u00a92021 Amarin Technologies \nTodos los derechos reservados - Desarrollo by <u>Cuervo estudio<\/u><\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3ebecc6\" data-id=\"3ebecc6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Un oral thin film(OTF) es un film muy delgado compuesto por una matriz polim\u00e9rica mono o multicapa que se aplica en la boca.<\/p>","protected":false},"author":6,"featured_media":9073,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-9068","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-and-society"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Oral Thin Film(OTF)<\/title>\n<meta name=\"description\" content=\"An oral thin film (OTF) is a very thin film made up of a single or multilayer polymeric matrix applied in the mouth.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/amarintech.com\/es\/oral-thin-filmotf\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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