{"id":9079,"date":"2022-07-28T20:57:55","date_gmt":"2022-07-28T20:57:55","guid":{"rendered":"https:\/\/www.amarintech.com\/?p=9079"},"modified":"2022-07-29T01:23:52","modified_gmt":"2022-07-29T01:23:52","slug":"api-characteristics-for-transdermal-drug-delivery-systems","status":"publish","type":"post","link":"https:\/\/amarintech.com\/es\/api-characteristics-for-transdermal-drug-delivery-systems\/","title":{"rendered":"Caracter\u00edsticas de los IFA para sistemas de administraci\u00f3n de f\u00e1rmacos transd\u00e9rmicos"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"9079\" class=\"elementor elementor-9079\">\n\t\t\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-c78867c elementor-section-height-min-height she-header-yes elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"c78867c\" data-element_type=\"section\" 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data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-22fcc07 elementor-widget elementor-widget-image\" data-id=\"22fcc07\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/amarintech.com\/es\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2000\" height=\"638\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2023\/11\/Amarin-Listado-de-Productos.pdf\" class=\"attachment-full size-full wp-image-5849\" alt=\"\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-442b119\" data-id=\"442b119\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-0e68f5c elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"0e68f5c\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_bottom&quot;:&quot;mountains&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-shape elementor-shape-bottom\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" opacity=\"0.33\" d=\"M473,67.3c-203.9,88.3-263.1-34-320.3,0C66,119.1,0,59.7,0,59.7V0h1000v59.7 c0,0-62.1,26.1-94.9,29.3c-32.8,3.3-62.8-12.3-75.8-22.1C806,49.6,745.3,8.7,694.9,4.7S492.4,59,473,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" opacity=\"0.66\" d=\"M734,67.3c-45.5,0-77.2-23.2-129.1-39.1c-28.6-8.7-150.3-10.1-254,39.1 s-91.7-34.4-149.2,0C115.7,118.3,0,39.8,0,39.8V0h1000v36.5c0,0-28.2-18.5-92.1-18.5C810.2,18.1,775.7,67.3,734,67.3z\"\/>\n\t<path class=\"elementor-shape-fill\" d=\"M766.1,28.9c-200-57.5-266,65.5-395.1,19.5C242,1.8,242,5.4,184.8,20.6C128,35.8,132.3,44.9,89.9,52.5C28.6,63.7,0,0,0,0 h1000c0,0-9.9,40.9-83.6,48.1S829.6,47,766.1,28.9z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c82bb91\" data-id=\"c82bb91\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e6195d elementor-widget elementor-widget-heading\" data-id=\"2e6195d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Caracter\u00edsticas de los IFA para sistemas de administraci\u00f3n de f\u00e1rmacos transd\u00e9rmicos <\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f45fc6c elementor-widget elementor-widget-text-editor\" data-id=\"f45fc6c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Alejandro Scasso\u00a0<\/strong>\u2013 Gerente de Tecnolog\u00eda Farmac\u00e9utica<\/p><div id=\"gtx-trans\" style=\"position: absolute; left: -20px; top: -9px;\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-c9ded8a\" data-id=\"c9ded8a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-62b6c1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"62b6c1f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-97230eb\" data-id=\"97230eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-003eebf elementor-widget elementor-widget-spacer\" data-id=\"003eebf\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0e564a3 elementor-widget elementor-widget-text-editor\" data-id=\"0e564a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><em>Para que un IFA pueda ser administrado a trav\u00e9s de la piel debe cumplir con ciertas caracter\u00edsticas.<\/em><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44be759 elementor-widget elementor-widget-text-editor\" data-id=\"44be759\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Visto desde diferentes \u00e1ngulos, la administraci\u00f3n de f\u00e1rmacos a trav\u00e9s de la piel ofrece ventajas incomparables<\/p><ul><li>Evita el primer paso de metabolismo hep\u00e1tico lo que permite reducir la dosis de ingesta para conseguir efecto terap\u00e9utico<\/li><li>F\u00e1cil administraci\u00f3n en comparaci\u00f3n con formas de dosificaci\u00f3n inyectables, intranasales e incluso orales cuando se altera el proceso de degluci\u00f3n<\/li><li>Medici\u00f3n precisa de la dosis, especialmente cuando se trata de parches transd\u00e9rmicos<\/li><li>F\u00e1cil manejo del medicamento por parte de los pacientes y los prestadores de salud<\/li><li>Amplios periodos de administraci\u00f3n, que comprende desde horas hasta una semana s<\/li><li>No invasivo<\/li><li>Liberaci\u00f3n controlada de f\u00e1rmacos especialmente \u00fatil en la administraci\u00f3n cr\u00f3nica de analg\u00e9sicos y terapias de reemplazo hormonal<\/li><li>Interrupci\u00f3n mas r\u00e1pida de la dosificaci\u00f3n con respecto otros medicamentos de liberaci\u00f3n extendida<\/li><\/ul><p>\u00a0<\/p><p>En este art\u00edculo, se consideran \u00fanicamente las formas de dosificaci\u00f3n transd\u00e9rmica \"pasiva\", en la que el f\u00e1rmaco difunde libremente a trav\u00e9s de la piel debido a un gradiente qu\u00edmico que act\u00faa como \"fuerza impulsora\". Otras formas de dosificaci\u00f3n \"activas\" requieren de energ\u00eda adicional para administrar el f\u00e1rmaco. Tiene sentido mencionar dentro de este grupo, los dispositivos iontofor\u00e9ticos donde, una corriente el\u00e9ctrica, fuerza el paso del f\u00e1rmaco ionizado a trav\u00e9s de la piel. Las microagujas y la electroporaci\u00f3n provocan una alteraci\u00f3n mec\u00e1nica o t\u00e9rmica de los poros del estrato c\u00f3rneo para favorecer el paso de los medicamentos.<\/p><p>\u00a0<\/p><p>Nos centramos especialmente en parches m\u00e1s que en geles y cremas. Sin embargo, debe reconocerse que las formas de dosificaci\u00f3n semis\u00f3lidas han demostrado ser seguras y eficientes para administrar hormonas, corticoides y antiinflamatorios, convirti\u00e9ndose en medicamentos claves para determinadas enfermedades.<\/p><p>\u00a0<\/p><p>Si bien las ventajas de la administraci\u00f3n transd\u00e9rmica parecen ser sobresalientes para un gran n\u00famero de f\u00e1rmacos y terapias, solo una cantidad reducida de productos transdermales se encuentran disponibles en todo el mundo.<\/p><p>\u00a0<\/p><p>La raz\u00f3n principal de la existencia limitada de medicamentos administrados por v\u00eda transd\u00e9rmica es consecuencia de las caracter\u00edsticas de los API involucrados, expresamente, el tama\u00f1o de la mol\u00e9cula y la dosis terap\u00e9utica. De hecho, no todos los API son propensos a administrarse a trav\u00e9s de la piel para producir un efecto terap\u00e9utico cient\u00edficamente probado.<\/p><p>\u00a0<\/p><p>El panorama para la administraci\u00f3n transd\u00e9rmica \"pasivo\" se reduce repentinamente a mol\u00e9culas de tama\u00f1o peque\u00f1o, descartando del escenario muchas terapias actuales, altamente eficientes, que involucran mol\u00e9culas de tama\u00f1o mediano y grande.<\/p><p>\u00a0<\/p><p>En t\u00e9rminos generales, se acepta que un API es factible de administrarse por v\u00eda transd\u00e9rmica si cumple con los siguientes atributos:<br \/><br \/><\/p><ul><li><strong>Peso molecular &lt; 400 D<\/strong><\/li><li><strong>Dosis diaria &lt; 20 mg\/d\u00eda<\/strong><\/li><li><strong>Punto de fusi\u00f3n &lt; 200 \u00baC<\/strong><\/li><li><strong>Lipofilicidad logP<sub>O\/W<\/sub>: \u20131.0 and 4.0<\/strong><\/li><li><strong>Ligeramente soluble en agua<\/strong><\/li><li><strong>Vida media &lt; 10 h<\/strong><\/li><li><strong>No irritante y no sensibilizante<\/strong><\/li><\/ul><p>\u00a0<\/p><p>La permeabilidad de un f\u00e1rmaco se define como la cantidad que difunde a trav\u00e9s de un cent\u00edmetro cuadrado de piel intacta durante un per\u00edodo finito de tiempo. Por lo tanto, la dosis administrada puede alcanzarse ajustando el \u00e1rea de la piel afectada y el per\u00edodo de tiempo involucrado. Debe considerarse que existe un umbral racional, que limita, a partir del uso y la comodidad del paciente, el tama\u00f1o aceptable de un parche transd\u00e9rmico.<br \/><br \/><\/p><p>Vinculado con el tama\u00f1o, los parches ofrecen claras ventajas sobre los geles y cremas, ya que el \u00e1rea de la piel involucrada est\u00e1 muy bien definida por la superficie del parche, mientras que en los semis\u00f3lidos, el \u00e1rea afectada es m\u00e1s dif\u00edcil de limitar ya sea en uno sola o en la administraci\u00f3n de dosis repetidas.<br \/><br \/><\/p><p>administraci\u00f3n de dosis repetidas.\nLa siguiente tabla resume las caracter\u00edsticas m\u00e1s relevantes de los IFA comercializadas en todo el mundo desde parches transdermicos<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a192ca3 elementor-widget elementor-widget-image\" data-id=\"a192ca3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/www.amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23.png\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"Screenshot 2022-07-28 at 18.15.23\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6OTA4MSwidXJsIjoiaHR0cHM6XC9cL2FtYXJpbnRlY2guY29tXC93cC1jb250ZW50XC91cGxvYWRzXC8yMDIyXC8wN1wvU2NyZWVuc2hvdC0yMDIyLTA3LTI4LWF0LTE4LjE1LjIzLnBuZyJ9\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"318\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-1024x407.png\" class=\"attachment-large size-large wp-image-9081\" alt=\"\" srcset=\"https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-1024x407.png 1024w, https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-300x119.png 300w, https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-768x306.png 768w, https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-1536x611.png 1536w, https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-2048x815.png 2048w, https:\/\/amarintech.com\/wp-content\/uploads\/2022\/07\/Screenshot-2022-07-28-at-18.15.23-18x7.png 18w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-447e865 elementor-widget elementor-widget-text-editor\" data-id=\"447e865\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><ul><li>Dosis transd\u00e9rmica m\u00e1s alta aprobada\/comercializada<\/li><li>Tama\u00f1o de parche m\u00e1s grande disponible en el mercado<\/li><li>Dosis diaria basada en 9 horas de exposici\u00f3n. Extrapolado a 24 horas podr\u00eda llegar a 80 mg\/d\u00eda<\/li><\/ul><p>\u00a0<\/p><p>Como se puede observar, no todos los IFA comercializados con \u00e9xito en el mercado transd\u00e9rmico cumplen con todos los atributos te\u00f3ricos.<\/p><p>La Buprenorfina tiene un peso molecular superior a 400, sin embargo, un parche bien formulado puede alcanzar las dosis objetivo.<\/p><p>La Rotigotina supera la lipofilicidad deseable, sin embargo, es un producto exitoso y hoy en d\u00eda, la \u00fanica forma de dosificaci\u00f3n para la administraci\u00f3n de Rotigotina.<\/p><p>El Metilfenidato representa el parche con la dosis diaria m\u00e1s alta administrada.<\/p><p>La Capsaicina es, con mucho, el parche m\u00e1s grande y el que se aplica por menos tiempo.<\/p><p>El tama\u00f1o del parche var\u00eda de menos de 10 cm2 a 280 cm2 cent\u00edmetros. Por lo general, se acepta que el tama\u00f1o deseable de un parche sea menor de 75 cm2. Los parches m\u00e1s grandes ser\u00e1n menos c\u00f3modos de usar y m\u00e1s complicados de manejar.<\/p><p>Como no hay una regla fija y se han visto varias excepciones, un breve estudio de factibilidad de laboratorio es la herramienta de toma de decisiones que ofrece Amarin para identificar candidatos a f\u00e1rmacos transd\u00e9rmicos.<\/p><p>Un estudio de factibilidad considera la elaboraci\u00f3n de prototipos sencillos. Significa combinar el IFA de inter\u00e9s en adhesivos seleccionados y evaluar la permeaci\u00f3n y la estabilidad del f\u00e1rmaco para concluir si las dosis terap\u00e9uticas del IFA en consideraci\u00f3n se pueden administrar desde una de parche de tama\u00f1o razonable y adem\u00e1s predecir las futuras dificultades y limitaciones para llevar a cabo un programa de desarrollo completo.<\/p><p>Hay docenas de API relativamente nuevos que han demostrado ser seguros y eficientes para varias terapias y poseen caracter\u00edsticas fisicoqu\u00edmicas ideales para convertirse en buenos candidatos para la administraci\u00f3n transd\u00e9rmica.<\/p><p>Si est\u00e1 interesado en explorar una API en particular para la administraci\u00f3n transd\u00e9rmica, no dude en comunicarse con el equipo de Amarin para analizar ideas y establecer actividades de factibilidad.<\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-inner-section elementor-element elementor-element-1780379 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1780379\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-d257fda\" data-id=\"d257fda\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-677db80 elementor-widget elementor-widget-spacer\" data-id=\"677db80\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-5a9c0c8a elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"5a9c0c8a\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3cd2d944\" data-id=\"3cd2d944\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90af84d elementor-widget elementor-widget-heading\" data-id=\"90af84d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Suscribite a <br>#AmarinNews<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1bd8c0a\" data-id=\"1bd8c0a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-ea25cb4 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"ea25cb4\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-24a9a85\" data-id=\"24a9a85\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c5e1f01 elementor-widget elementor-widget-menu-anchor\" data-id=\"c5e1f01\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"contactforn\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-inner-section elementor-element elementor-element-408b4f4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"408b4f4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-66c23bc\" data-id=\"66c23bc\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aa37af1 elementor-widget elementor-widget-heading\" data-id=\"aa37af1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">\u00a1As\u00f3ciese con nosotros!<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cabcea0 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"cabcea0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_delay&quot;:200}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Ofrecemos experiencia y \u201cknow how\u201d; y al mismo tiempo, flexibilidad y adaptabilidad a los requerimientos de nuestros clientes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc7fbe4 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"cc7fbe4\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"mailto:info@amarintech.com.ar\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-envelope\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">info@amarintech.com.ar<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"tel:+54%2011%204588-6500\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone-alt\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">+54 11 4588-6500<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-map-marker-alt\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Sanchez 2045 (C1416BQG), Buenos Aires, Argentina.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-556486e\" data-id=\"556486e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-b8751dc elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"b8751dc\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2d4bb11\" data-id=\"2d4bb11\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-top-section elementor-element elementor-element-9eb582d elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"9eb582d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a96dec3\" data-id=\"a96dec3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aebc9b3 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"aebc9b3\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"has_eae_slider elementor-section elementor-inner-section elementor-element elementor-element-11b4142 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default\" data-id=\"11b4142\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-0dfdbb6\" data-id=\"0dfdbb6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-46f306b\" data-id=\"46f306b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de8a252 elementor-widget elementor-widget-image\" data-id=\"de8a252\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"255\" src=\"https:\/\/amarintech.com\/wp-content\/uploads\/2021\/01\/LOGOBW-1024x327.png\" 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class=\"elementor-element elementor-element-4c55c47 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"4c55c47\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/amarintech.com\/es\/about-us\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Nosotros<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/amarintech.com\/es\/technology\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Tecnolog\u00eda<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li 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elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a1925e7\" data-id=\"a1925e7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-afb4c3b elementor-widget elementor-widget-heading\" data-id=\"afb4c3b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/www.cuervoestudio.com.ar\/\">Copyright \u00a92021 Amarin Technologies \nTodos los derechos reservados - Desarrollo by <u>Cuervo estudio<\/u><\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"has_eae_slider elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3ebecc6\" 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