The Microbiome and Neurodegenerative Diseases: Evidence, Limitations, and Opportunities for Transdermal CNS Development

The relationship between the gut microbiome and neurodegenerative diseases is one of the most actively researched fields of the past decade. Accumulated preclinical and clinical evidence suggests the microbiota may play a key role in susceptibility to and progression of conditions such as Parkinson's and Alzheimer's disease. At the same [...]

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Ethical Alternatives to Animal Experimentation: Advances in In Vitro Models and Their Relevance for Transdermal System Development

In recent years, the pharmaceutical and life sciences industry has intensified its search for alternatives to animal experimentation. This trend responds to three simultaneous pressures: growing concern for animal welfare, scientific doubts about the validity of extrapolating animal data to humans, and the increasing availability of alternative methodologies yielding more [...]

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